Pyrin domain



Pyrin domain (PYD) is a protein domain known as death fold. This domain allows the protein to interact with other pyrin domains. It is also known as PYD or PAAD/DAPIN or marenostrin domain. Proteins containing pyrin domain are involved in inflammation and apoptosis. The NALP proteins contain domains NACHT, LRR and PYD and are part of the inflammasome. A 781-amino acid protein named pyrin contains a PYD domain in its N-terminal. Mutations in the protein are the cause of Familial Mediterranean fever.

3D Structures of Pyrin domain
2km6 – hPYD in NLRP7 – human – NMR 2wl1 – hPYD PRYSPRY residues 586-776

2do9 – mPYD in NALP10 – mouse – NMR 2yu0 – mPYD in interferon-activable protein 205 - NMR 1pn5 – hPYD in NALP1 - NMR 1ucp - hPYD in apoptosis-associated speck-like protein – NMR 2hm2 – hPYD in apoptosis-associated speck-like protein2 – NMR 2dbg – hPYD in myeloid cell nuclear differentiation antigen - NMR